In celebration of the 75th NFL Draft, which kicks off in primetime for the first time on Thursday, April 22, fans chose the 75 Most Valuable Draft Picks of all time presented by Verizon. Nearly 45 million votes were cast from March 12 – April 18 on NFL.com.
The NFL announced today selections 25 – 11. Picks 75 – 51 were announced on Monday, April 19 and picks 50 – 26 on Tuesday, April 20 on NFL.com and NFL Network. The top 10 greatest Draft picks will be revealed during the 2010 NFL Draft, which begins Thursday, April 22 at 7:30 PM ET. The Second and Third Rounds of the Draft will be on Friday, April 23 at 6:00 PM ET followed by Rounds 4-7 on Saturday, April 24 at 10:00 AM ET.
The 10 Most Valuable Draft Picks will be announced during Round 1, when many of the Top 10 will be in attendance at Radio City Music Hall, the home of the 2010 NFL Draft. The order of the Top 10 will be revealed following the conclusion of the Second Round of the Draft on Friday night. Some of these players will be on hand for the announcement.
NFL.com editors narrowed down the first 74 Drafts to a list of the top 320 players, consisting of 10 players from each team. Fans began the process of determining the Most Valuable Draft Pick by choosing between pairs of players randomly generated from the list of 320 greats.
11 – 25 MOST VALUABLE DRAFT PICKS OF ALL TIME AS SELECTED BY FANS ON NFL.COM
(The team listed is the team that drafted the player.)
| Rank | Name | Team | Year; Round, Pick |
| 11 | Mike Singletary | Chicago Bears | 1981; 2, 38 |
| 12 | Jim Brown | Cleveland Browns | 1957; 1, 6 |
| 13 | Terry Bradshaw | Pittsburgh Steelers | 1970; 1, 1 |
| 14 | Ray Lewis | Baltimore Ravens | 1996; 1, 26 |
| 15 | Troy Aikman | Dallas Cowboys | 1989; 1, 1 |
| 16 | Randy Moss | Minnesota Vikings | 1998; 1, 21 |
| 17 | Deion Sanders | Atlanta Falcons | 1989; 1, 5 |
| 18 | Ronnie Lott | San Francisco 49ers | 1981; 1, 8 |
| 19 | Rod Woodson | Pittsburgh Steelers | 1987; 1, 10 |
| 20 | Dick Butkus | Chicago Bears | 1965; 1, 3 |
| 21 | Drew Brees | San Diego Chargers | 2001; 2, 32 |
| 22 | LaDainian Tomlinson | San Diego Chargers | 2001; 1, 5 |
| 23 | Roger Staubach | Dallas Cowboys | 1964; 10, 129 |
| 24 | Marshall Faulk | Indianapolis Colts | 1994; 1, 2 |
| 25 | Joe Greene | Pittsburgh Steelers | 1969; 1, 4 |
